Traditional medicine has been used for thousands of years with great contributions made by practitioners to human health, particularly as primary health care providers at the community level. Eighty per cent of African populations use some form of traditional herbal medicine. With this, there is need for a quality and standard drugs for the wellbeing of the people who use it. As attention and public funding for international traditional herbal medicine research collaborations grows, more detailed analysis of ethical issues in this research is warranted. The emphasis on research is safety and efficacy studies for herbal remedies that are currently in use to treat illnesses of public health importance with resultant product development that targets national and international markets. THETA Uganda, has been at the forefront of traditional medicine use and practice in Uganda. It started as a research project in 1992, carrying out research on alternative therapies for treatment of HIV/AIDS at the time of no ARVS. Since then THETA has been operating country-wide with a core mandate of improving health and access to health care through; promotion of research in traditional medicine; strengthening capacity of communities for holistic health care and building models for traditional and convectional medicine integration. With the increasing interest in herbal medicine research, THETA Uganda formulated and developed Guidelines for research involving Humans as research participants have been formulated to provide a system to facilitate the review of research without compromising the rights and welfare of individual research participants. The guideline are in alignment with the current norms of scientific research and ethical conduct. Following the development of research guidelines, applications for the accreditation of the THETA REC were sent to UNSCT to ensure that their certification practices are acceptable and competent to test and certify the research done on human subjects. The accreditation of the REC Office, following procedures happened on 6th September 2016. A researcher therefore interested in carrying out research in traditional medicine can submit their research protocol for review by the Research and Ethics Committee to ensure research compliance with the national guidelines by UNCST on ethical conduct for research involving human participants. For more information on the THETA REC email us at email@example.com or call +256-701619858.